BioScience Trends. 2010;4(6):325-332. (DOI: )

Association between circulating leptin and insulin resistance, the lipid profile, and metabolic risk factors in North Indian adult women.

Gupta A, Gupta V, Agrawal S, Natu SM, Agrawal CG, Negi MPS, Tiwari S

Leptin plays an important role in the regulation of body weight and operates by inhibiting food intake and stimulating energy expenditure. The purpose of the present study was to ascertain the relationship between serum leptin levels and the lipid profile, insulin resistance, and metabolic risk factors in North Indian adult women. In a transactional case-control study of 390 women, subjects were 186 women with metabolic syndrome according to National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP) guidelines and 204 healthy control women without metabolic syndrome, all of whom were between 20-40 years of age. Circulating leptin levels were determined by sandwich enzyme-linked immunosorbent assay, insulin resistance was determined by homeostasis model assessment for insulin resistance (HOMA-IR), and the lipid profile was determined using an enzymatic method. Results indicated that circulating leptin (13.38 ± 9.00 vs. 8.16 ± 6.31 ng/mL, p < 0.001), HOMA-IR (2.68 ± 2.05 vs. 1.72 ± 1.20, p < 0.001), the lipid profile, and other metabolic risk factors (waist circumference, waist-to-hip ratio, body mass index, and fasting plasma insulin) were significantly higher in women with metabolic syndrome than in women without the syndrome (p < 0.001). Further, in women with metabolic syndrome serum leptin was significantly (p < 0.05 or p < 0.001) and positively correlated with HOMA-IR (p = 0.000) and other metabolic risk factors but negatively correlated with fasting plasma glucose, triglycerides, and high-density lipoprotein cholesterol. Circulating leptin was found to be significantly associated with hyperlipidemia, insulin resistance, and other metabolic risk factors in North Indian adult women.

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